Download e-book for kindle: Admixture Dynamics, Natural Selection and Diseases in by Wenfei Jin

By Wenfei Jin

ISBN-10: 9401774064

ISBN-13: 9789401774062

ISBN-10: 9401774080

ISBN-13: 9789401774086

ISBN-10: 9535105884

ISBN-13: 9789535105886

In this thesis, Dr. Jin offers the distribution of ancestral chromosomal segments within the admixed genome, that can give you the info had to discover inhabitants admixture dynamics. the writer derives actual inhabitants histories of African american citizens and Mexicans utilizing genome-wide unmarried nucleotide polymorphisms (SNPs) info. Mapping the genetic history allows the learn of typical choice within the admixed inhabitants, and the writer identifies the indications of choice in African american citizens in view that their African ancestors left for the United States. He additional demonstrates that a few of the choice signs have been linked to African American-specific high-risk ailments resembling prostate melanoma and high blood pressure, suggesting an incredible position those disease-related genes may need performed in adapting to their new setting. finally, the writer unearths the complexity of typical choice in shaping human susceptibility to affliction. The thesis considerably advances our knowing of the new inhabitants admixture, version to neighborhood atmosphere and its future health implications.

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Additional resources for Admixture Dynamics, Natural Selection and Diseases in Admixed Populations

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Hey J, Machado CA. The study of structured populations–new hope for a difficult and divided science. Nat Rev Genet. 2003;4:535–43. Ramachandran S, et al. Support from the relationship of genetic and geographic distance in human populations for a serial founder effect originating in Africa. Proc Natl Acad Sci USA. 2005;102:15942–7. Li JZ, et al. Worldwide human relationships inferred from genome-wide patterns of variation. Science. 2008;319:1100–4. Cann HM, et al. A human genome diversity cell line panel.

Balaresque PL, Ballereau SJ, Jobling MA. Challenges in human genetic diversity: demographic history and adaptation. Hum Mol Genet. 2007;16(R2):R134–9. Nielsen R, Hellmann I, Hubisz M, Bustamante C, Clark AG. Recent and ongoing selection in the human genome. Nat Rev Genet. 2007;8:857–68. Hancock AM, et al. Adaptations to climate in candidate genes for common metabolic disorders. PLoS Genet. 2008;4:e32. 46. Sabeti PC, et al. Positive natural selection in the human lineage. Science. 2006;312:1614–20.

Then, after T generations, the distribution of LACS from pop1 in the admixed population would follow an expo1 , as shown below. 1) where distribution of LACS in HI model was influenced by the genetic contribution of parental population (m) and the number of generations (T). In short, the lesser the genetic contribution from parental population (m), the shorter the ancestral chromosomal segments; the larger the number of generations (T), the shorter the ancestral chromosomal segments. 1b) model, parental populations gradually contributed their genetic material to the admixed population over T generations.

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Admixture Dynamics, Natural Selection and Diseases in Admixed Populations by Wenfei Jin


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