By S. Eva Singletary, Geoffrey L. Robb
Edited through amazing leaders within the box of breast ailment (Dr. Singletary chairs the Breast melanoma Committee for the yank university of Surgeons), this publication bargains first-hand recommendation on prevention, prognosis, remedy and reconstruction by way of well-known specialists. The paintings positive factors the private remedy protocols of the head physicians and surgeons focusing on breast disorder. stipulations lined comprise benign and malignant tumors, endocrine and irritating issues, and adolescent and grownup difficulties in either men and women. Key positive factors: - comprises authoritative recommendation in accordance with the scientific adventure of famous investigators - offers a pretty good assessment of breast affliction, beginning with breast screening, and advancing to issues reminiscent of silicone autoimmune affliction and breast reconstruction recommendations - Takes a well-rounded method of sufferer therapy, with articles on psychosocial difficulties relating to breast melanoma, and the follow-up care of the breast melanoma sufferer - followed through a CD-ROM with the whole textual content and illustrations of the publication, in totally searchable PDF documents viewers: scholars and practitioners in surgical procedure, plastic and reconstructive surgical procedure, oncology, and gynecology.
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Additional info for Advance Therapy of Breast Disease
Am J Hum Genet 1998;62:145-58. 33. Varley JM, McGown G, Thorncroft M, et al. Germ line mutations of TP53 in Li-Fraumeni families: an extended study of 39 families. Cancer Res 1997; 57:3245-52. 34. Friedman E, Bruchim RBAS, Kurglikova A, et al. Double heterozygotes for the Ashkenazi founder mutations in BRCA- 1 and BRCA-2 genes. Am J Hum Genet 1998;63:1224-7. 35. Ford D, Easton DF, Bishop DT, et al. Breast Cancer Linkage Consortium. Risks of cancer in BRCA-1 mutation carriers. Lancet 1994;343:692-5.
Once a family is considered appropriate for BRCA- 1/ BRCA-2 genetic analysis, one must consider which relative would provide the most information. The individual seeking consultation may not be the most appropriate initial family member to be tested. In general, a relative who has had breast or ovarian cancer at a young age should be tested first. This is not always possible if such relatives are deceased, or not interested in testing. In these cases, testing can be offered to individuals unaffected with cancer, but they must be counseled that a negative result in the absence of a known mutation is not useful because the underlying cause of cancer in the family has not been identified.
When necessary, the pedigree should be expanded to include pertinent diagnoses in nieces, nephews, and cousins as well. Cancer information should include the specific diagnoses and age at each diagnosis for each relative. These data are sought in recognition of several facts: (1) breast cancer susceptibility can be inherited through the paternal as well as maternal lineage; (2) non-breast cancer diagnoses may help delineate specific family cancer syndromes; (3) early age at diagnosis is a feature of hereditary cancers; and (4)individuals with genetic predisposition are more likely to develop multiple primary neoplasms.
Advance Therapy of Breast Disease by S. Eva Singletary, Geoffrey L. Robb