Download PDF by Oliver Werz, Jenny Klemm, Olof Rådmark, Bengt Samuelsson: Advances in Prostaglandin and Leukotriene Research: Basic

By Oliver Werz, Jenny Klemm, Olof Rådmark, Bengt Samuelsson (auth.), Bengt Samuelsson, R. Paoletti, Giancarlo C. Folco, E. Granström, S. Nicosia (eds.)

ISBN-10: 9048158818

ISBN-13: 9789048158812

ISBN-10: 9401597219

ISBN-13: 9789401597210

This quantity is the complaints of the eleventh overseas convention on Advances in Prostaglandin and Leukotriene study: easy technological know-how and New scientific purposes, held in Florence, Italy, on June 4-8, 2000, which maintains the culture of overlaying either easy and medical points of prostaglandin and leukotriene examine.

At this assembly specific emphasis used to be given to the aptitude program of the unconventional COX-2 inhibitors, the genetics of bronchial asthma when it comes to the construction of leukotrienes, and novel mobile networks for the creation of leukotrienes and lipoxins.

Traditionally, as has been performed in earlier conferences of this sequence, a large amount of new fabric was once provided and mentioned this yr, with specific awareness given to the most recent scientific data.

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Extra info for Advances in Prostaglandin and Leukotriene Research: Basic Science and New Clinical Applications

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Nakielny S, Dreyfuss G. Nuclear export of proteins and RNAs. Curr Opin Cell Biol 1997; 9:420-29. Brock T, McNishR, Bailie M, Peters-Golden M. Rapid importof cytosolic 5-lipoxygenase into the nucleus of neutrophils after in vivo recruitment and in vitro adherence. J Biol Chem 1997;272:8276-80. Covin R, Brock T, Bailie M, Peters-Golden M. Altered expression and localization of 5lipoxygenase accompany macrophage differentiation in the lung. Am J Physiol (Lung Cell Mol Physiol) 1998; 275:L303-L310.

Molecular cloning of thc gene for human leukotriene C4 synthase. Organization, nucleotide sequence, and chromosomallocalization to 5q35. J Biol Chem 1996;271: 11356-61. Bigby TD, Hodulik CR, Arden KC, Fu L. Molecular cloning ofthe human leukotriene C4 synthase gene and assignment to chromosome 5q35. Mol Med 1996;2:637-46. Sanak M, Simon HU, Szczeklik A. Leukotriene C4 synthase promoter polymorphism and risk of aspirin-induced asthma. Lancet 1997;350: 1599-600. Van Sambeek R, Stevenson DD, Baldasaro M, et al.

39 We also observed the localization of LTA4H in rat alveolar macrophages (AMs) with immunocytochemistry (Figure 4) and CHO cells stably expressing LTA4H and EGFP fusion protein (data not shown). Freshly collected AMs from BALF showed LTA 4H was localized mainly to the cytosol and after floating for 10 minutes the enzyme partially translocated into the nucleus. This localization and translocation were also observed in CHO cells. The translocation was inhibited when CHO cells were treated with tyrosine kinase inhibitors, or when FCS was starved from the medium.

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Advances in Prostaglandin and Leukotriene Research: Basic Science and New Clinical Applications by Oliver Werz, Jenny Klemm, Olof Rådmark, Bengt Samuelsson (auth.), Bengt Samuelsson, R. Paoletti, Giancarlo C. Folco, E. Granström, S. Nicosia (eds.)

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