By Jeffrey M. Drazen (auth.), Zeliha Yazici, Giancarlo C. Folco, Jeffrey M. Drazen, Santosh Nigam, Takao Shimizu (eds.)
This quantity, the complaints of the twelfth overseas convention on Advances in Prostaglandin, Leukotriene and different Bioactive Lipid examine: simple technological know-how and scientific functions, held August 25-29, 2002, in Istanbul, Turkey, discusses advances in bioactive lipid examine with certain realization to melanoma, cardiovascular ailments, gastrointestinal ailments and respiration illnesses. particular subject matters coated comprise the position of leukotrienes and lipoxins in irritation, the cytochrome P450 pathway, the genetics and genomics of bioactive lipids, lipid peroxidation, apoptosis, angiogenesis, isoprostanes, receptors and inhibitors, cyclooxygenase and lipoxygenase pathways and inhibitors, prostaglandin synthases and receptor signaling, phospholipases and inhibitors.
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Additional info for Advances in Prostaglandin, Leukotriene, and other Bioactive Lipid Research: Basic Science and Clinical Applications
Regulation of airway hyper-responsiveness by LXa. OVA sensitized mice were treated with LX analog or vehicle prior to OVA aerosol challenge . Airway reactivity was determined by methacholine-dependent change in lung resistance and calculation of the effective dose of methacholine resulting in a 200% increase in lung resisitance (EDzoo). 2:6). Administration of LXa significantly reduced tissue eosinophils, lymphocytes and vascular injury . In BAL fluids, there was dosedependent inhibition of total leukocytes, eosinophils and lymphocytes.
Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenase. Proc Nat! Acad Sci USA 1992; 89(1): 217-221. Vanderhoek JY. Role of the 15-lipoxygenase in the immune system. Ann N Y Acad Sci, 1988; 524: 240-251. Johnson HG, ML McNee, and FF Sun. 15-Hydroxyeicosatetraenoic acid is a potent inflammatory mediator and agonist of canine tracheal mucus secretion. Am Rev Respir Dis, 1985; 131(6): 917-922. Profita M et aI. 15(S)-HETE release and reincorporation modulate LTB 4 production and neutrophil chemotaxis in chronic bronchitis.
Acknowledgements This work was supported in part by a grant from the National Institutes of Health (HL25785). COVALENT BINDING OF LEUKOTRIENE A4 TO NUCLEOSIDES 33 References 1. 2. 3. 4. 5. 6. 7. 8. Fitzpatrick FA, Morton DR, Wynalda MA. Albumin stabilizes leukotriene ~. J Biol Chern 1982; 257:4680-4683. Bigby TD. The yin and the yang of 5-lipoxygenase pathway activation. Mol Phannacol 2002; 62:200-202. Reiber DC, Murphy RC. Covalent binding of LTA4 to nucleosides and nucleotides. Arch Biochern Biophys 2000; 379:119-126.
Advances in Prostaglandin, Leukotriene, and other Bioactive Lipid Research: Basic Science and Clinical Applications by Jeffrey M. Drazen (auth.), Zeliha Yazici, Giancarlo C. Folco, Jeffrey M. Drazen, Santosh Nigam, Takao Shimizu (eds.)