M.D. Fulton Roberts's An Introduction to Human Blood Groups PDF

By M.D. Fulton Roberts

ISBN-10: 1483256758

ISBN-13: 9781483256757

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I t is also of interest, and may be rele­ vant, t h a t the immune forms of anti-A or anti-B giving rise to hsemolytic disease of the newborn seem to arise far more commonly in mothers of Group O than in those of Group A or B. Neither of these observations has yet been satisfactorily explained. HiEMOLYTic D I S E A S E OF THE N E W B O R N Hsemolytic disease due to A or B differs in certain respects from the condition, already described, t h a t results from R h immunisation. Clinically there are no very great differences, though the disease due to anti-A or anti-B is usually milder (but it can be severe) and in its mild form may be quite common.

But the formation of these blood-group substances on the cells and in the secretions is governed by a number of independently acting genes. One of these genes, called X, is necessary for the development of the B antigen both on the cells and in the secretions (it may also influence the A antigen, but of this we have no evidence). e. inheritence of xx) thus causes failure of development of the B antigen in persons known to have received a B gene. The second gene, Y, influences the development of the A antigen (but does not concern B) on the cells, but it does not modify the secretion of the A antigen.

This represents the minimum safeguard which must be made available to every patient. Some patients 62 HUMAN BLOOD GROUPS require further careful and detailed preparation, for example those likely to receive repeated transfusions or otherwise suspected of an unusual predisposition to manufacture antibodies. I t is important t h a t the idea does not gain ground t h a t much of this preparation can be circumvented by administering blood of Group O dd indiscriminately. There are many reasons for this, of which a practical one is the difficulty the blood transfusion service would encounter in trying to meet a large demand for this far from common type of blood.

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An Introduction to Human Blood Groups by M.D. Fulton Roberts


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